protein translocation การใช้

• The SRP-SRP receptor complex dissociates via GTP hydrolysis and the cycle of SRP-mediated protein translocation continues.
• The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum ( ER ) membrane.
• This raises the possibility about existence of yet-unidentified specific mechanisms for protein translocation from mitochondria to other cellular destinations.
• The signal sequence receptor ( SSR ) is a glycosylated endoplasmic reticulum ( ER ) membrane receptor associated with protein translocation across the ER membrane.
• The metaxin gene, which encodes a protein located on the outer membrane of mitochondria, is a component of the mitochondrial protein translocation apparatus.
• The appearance of molecular markers for satellite secretory pathways provides further evidence that the spine apparatus plays a role in local integral membrane protein translocation and processing.
• More specifically, the protein translocation site marker ( Sec61? ) and the Golgi cisternae markers ( giantin and ?-mannosidase II ) have been observed in the spine apparatus.
• The current model of protein translocation is that the translocon ( translocator ) acts as a channel through the hydrophobic membrane of the endoplasmic reticulum ( after the SRP has dissociated and translation is continued ).
• Besides cytochrome c oxidase subunits, extramitochondrial localization has also been observed for large numbers of other mitochondrial proteins ., This raises the possibility about existence of yet unidentified specific mechanisms for protein translocation from mitochondria to other cellular destinations.
• It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER . The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway.